The Library

Cat’s Claw

Here is a study on the plant Cat’s Claw and its potential for preventing/repairing hearing loss after noise damage.

Something @bronzeagemantis briefly mentions in episode fourteen of Caribbean Rhythms (POLITICAL CONSERVATIONISM).

Uncaria tomentosa = Cat’s Claw

Carboxy alkyl esters (CAE) are the bioactive components of the hydrophilic chemotypes in cat’s claw that are consumed, for instance, when the plant is boiled in water.

Benefits of CAEs: antioxidant protection, augmentation of DNA repair, anti-inflammation and immunomodulation.CAEs of UT (cat’s claw) have demonstrated efficacy as a multifunctional cytoprotective agent in both human and animal studies.

The combined results (below) suggest that CAE treatment facilitated almost complete recovery of OHC (outer hair cell) function following noise injury.

Sensory function as determined by distortion product otoacoustic emission (DPOAE) revealed that CAE treatment preserved OHC activity following noise exposure.

Subjects not treated with CAEs of UT showed that noise exposure induced permanent loss of DPOAE levels 1–4 weeks later.

Compound action potential (CAP) recordings suggested that CAE treatment limited neural impairment following noise exposure.

Cytocochleograms of OHC counts from each group revealed that the noise exposure induced cellular loss, but CAE treatment limited the magnitude of the loss.

These findings suggest that CAEs may enhance the recovery of OHC function from both temporary (1 week) and permanent (4 weeks) noise-injury.

Antioxidants are needed to protect endogenous biomolecules such as DNA, proteins and lipids. Several human experiments have supported a role for CAE in antioxidation.

Humans treated with CAE showed a significant increase in blood plasma antioxidation levels which lead to beneficial systemic effects such as increased energy and concentration coupled with reduced incidence of headaches, general pain, sore throat, diarrhea and fatigue.

A notable volume of human, animal and in vitro experiments has demonstrated that treatment with CAEs of UT specifically augment endogenous DNA repair capacity which then restores cellular function after exposure to a variety of physical and chemical stressors.

Beyond a role in antioxidation, DNA repair & antiinflammation, CAEs are known to regulate endogenous molecules such as tryptophan, nicotinamide, collagen III, etc., & also function as protein synthesis enhancers, neuroprotectants, antibiotics, cytoprotectors and tumor inhibitors. 


This experiment tested the hypothesis that CAEs of UT (cat’s claw) will augment recovery of sensory and neuronal functions following noise injury. Most results indicated that CAEs of UT repaired hearing cell damage after exposure to noise up to 4 weeks later. 

This article was provided to BAPexandria courtesy of @ali__lennon

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